 |  |  | | | Diseases | |  | Chronic Lymphocytic Leukaemia Trials |
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| |  | Information Booklet |
A booklet produced by Leukaemia Research Fund giving background information on clinical trials is available to download.
Text version of the booklet
| Registers of Trials |
Current Controlled Trials
International Cancer Research Portfolio - a register of UK and US cancer research (including trials)
Last updated 14/11/2008
| Leukaemia Research sponsored trials |
| CLL4 - a randomised comparison of chlorambucil, fludarabine and fludarabine plus cyclophosphamide | | Trial Code: | 58585610 | | Type: | Phase III | | Status: | Open | | Link: | http://www.controlled-trials.com/mrct/trial/CHRONI... | | Website: | http://www.icr.ac.uk/haemcyto/CLL4/PDFs.html | | This new study will compare conventional therapy with chlorambucil versus the new agent fludarabine, used alone or in a novel combination with cyclophosphamide. End points of the trial will be: survival, response to therapy, duration of response, toxicity and quality of life. |
Last updated 14/11/2008
| Non-Leukaemia Research sponsored trials |
| The value of autografting in younger patients with high risk CLL | | Trial Code: | 69559570 | | Type: | Phase III | | Status: | Open | | Link: | http://www.controlled-trials.com/mrct/trial/CHRONI... | | Website: | http://www.ebmt.org/5WorkingParties/CLWP/clwp6.html | | This is a prospective randomised phase III trial designed to determine the outcome of autologous SCT compared to no further treatment at present in patients with high risk CLL who have reached a complete remission (CR), a very good partial remission (VGPR) or a nodular partial remission (NPR) (see appendix I for definitions) after first or second line therapy. |
| CLL8 - Phase III trial of combined immunochemotherapy with Fludarabine, Cyclophosphamide and Rituximab (FC-R) versus chemotherapy with Fludarabine and Cyclophosphamide (FC) alone in patients with previously untreated chronic lymphocytic leukaemia | | Trial Code: | 02757147 | | Type: | Phase III | | Status: | Open | | Link: | http://www.controlled-trials.com/mrct/trial/CLL8/2... | The objective of this study is to determine the value of immunochemotherapy with FCR in comparison with chemotherapy with FC alone in the first-line therapy of B-CLL. The study is to answer the following questions:
- Is combined immunochemotherapy with FCR superior to chemotherapy with FC alone in the first-line therapy of B-CLL?
- Is combined immunochemotherapy with FCR a safe alternative to FC chemotherapy alone with regards to the adverse effects? |
Last updated 14/11/2008 |
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